近年来，很少有射击对象检测（FSOD）蓬勃发展，通过转移丰富的基本类别获得知识来学习具有有限数据的新颖对象类。 FSOD方法通常假定两者几乎没有提供新的类别的示例，并且测试时间数据属于同一域。但是，此假设在各种工业和机器人技术应用中都不存在，在这种应用程序中，模型可以从源域中学习新颖的类别，同时从目标域中推断类。在这项工作中，我们解决了FSOD的零击域适应性（也称为域的概括）的任务。具体而言，我们假设目标域中新颖类的图像和标签都无法在训练过程中获得。我们解决域间隙的方法是两个方面。首先，我们利用元训练范式，在该范式上学习基本类别的域转移，然后将域知识转移到新颖的类别中。其次，我们在新型类别的几镜头上提出了各种数据增强技术，以说明所有可能的领域特定信息。为了将网络仅限于编码域 - 不可思议的类特异性表示，提出了对比损失，以最大程度地提高前景建议和类嵌入之间的相互信息，并将网络的偏见减少到目标域中的背景信息。我们对无T，Pascal-VOC和Exdark数据集进行的实验表明，所提出的方法成功地减轻了域间隙，而无需利用目标域中的标签或新型类别的图像。

Lidar sensors are costly yet critical for understanding the 3D environment in autonomous driving. High-resolution sensors provide more details about the surroundings because they contain more vertical beams, but they come at a much higher cost, limiting their inclusion in autonomous vehicles. Upsampling lidar pointclouds is a promising approach to gain the benefits of high resolution while maintaining an affordable cost. Although there exist many pointcloud upsampling frameworks, a consistent comparison of these works against each other on the same dataset using unified metrics is still missing. In the first part of this paper, we propose to benchmark existing methods on the Kitti dataset. In the second part, we introduce a novel lidar upsampling model, HALS: Height-Aware Lidar Super-resolution. HALS exploits the observation that lidar scans exhibit a height-aware range distribution and adopts a generator architecture with multiple upsampling branches of different receptive fields. HALS regresses polar coordinates instead of spherical coordinates and uses a surface-normal loss. Extensive experiments show that HALS achieves state-of-the-art performance on 3 real-world lidar datasets.

Coronary Computed Tomography Angiography (CCTA) provides information on the presence, extent, and severity of obstructive coronary artery disease. Large-scale clinical studies analyzing CCTA-derived metrics typically require ground-truth validation in the form of high-fidelity 3D intravascular imaging. However, manual rigid alignment of intravascular images to corresponding CCTA images is both time consuming and user-dependent. Moreover, intravascular modalities suffer from several non-rigid motion-induced distortions arising from distortions in the imaging catheter path. To address these issues, we here present a semi-automatic segmentation-based framework for both rigid and non-rigid matching of intravascular images to CCTA images. We formulate the problem in terms of finding the optimal \emph{virtual catheter path} that samples the CCTA data to recapitulate the coronary artery morphology found in the intravascular image. We validate our co-registration framework on a cohort of $n=40$ patients using bifurcation landmarks as ground truth for longitudinal and rotational registration. Our results indicate that our non-rigid registration significantly outperforms other co-registration approaches for luminal bifurcation alignment in both longitudinal (mean mismatch: 3.3 frames) and rotational directions (mean mismatch: 28.6 degrees). By providing a differentiable framework for automatic multi-modal intravascular data fusion, our developed co-registration modules significantly reduces the manual effort required to conduct large-scale multi-modal clinical studies while also providing a solid foundation for the development of machine learning-based co-registration approaches.

Artificial intelligence(AI) systems based on deep neural networks (DNNs) and machine learning (ML) algorithms are increasingly used to solve critical problems in bioinformatics, biomedical informatics, and precision medicine. However, complex DNN or ML models that are unavoidably opaque and perceived as black-box methods, may not be able to explain why and how they make certain decisions. Such black-box models are difficult to comprehend not only for targeted users and decision-makers but also for AI developers. Besides, in sensitive areas like healthcare, explainability and accountability are not only desirable properties of AI but also legal requirements -- especially when AI may have significant impacts on human lives. Explainable artificial intelligence (XAI) is an emerging field that aims to mitigate the opaqueness of black-box models and make it possible to interpret how AI systems make their decisions with transparency. An interpretable ML model can explain how it makes predictions and which factors affect the model's outcomes. The majority of state-of-the-art interpretable ML methods have been developed in a domain-agnostic way and originate from computer vision, automated reasoning, or even statistics. Many of these methods cannot be directly applied to bioinformatics problems, without prior customization, extension, and domain adoption. In this paper, we discuss the importance of explainability with a focus on bioinformatics. We analyse and comprehensively overview of model-specific and model-agnostic interpretable ML methods and tools. Via several case studies covering bioimaging, cancer genomics, and biomedical text mining, we show how bioinformatics research could benefit from XAI methods and how they could help improve decision fairness.

Physics-Informed Neural Networks (PINNs) are gaining popularity as a method for solving differential equations. While being more feasible in some contexts than the classical numerical techniques, PINNs still lack credibility. A remedy for that can be found in Uncertainty Quantification (UQ) which is just beginning to emerge in the context of PINNs. Assessing how well the trained PINN complies with imposed differential equation is the key to tackling uncertainty, yet there is lack of comprehensive methodology for this task. We propose a framework for UQ in Bayesian PINNs (B-PINNs) that incorporates the discrepancy between the B-PINN solution and the unknown true solution. We exploit recent results on error bounds for PINNs on linear dynamical systems and demonstrate the predictive uncertainty on a class of linear ODEs.

We show that for a plane imaged by an endoscope the specular isophotes are concentric circles on the scene plane, which appear as nested ellipses in the image. We show that these ellipses can be detected and used to estimate the plane's normal direction, forming a normal reconstruction method, which we validate on simulated data. In practice, the anatomical surfaces visible in endoscopic images are locally planar. We use our method to show that the surface normal can thus be reconstructed for each of the numerous specularities typically visible on moist tissues. We show results on laparoscopic and colonoscopic images.

A significant level of stigma and inequality exists in mental healthcare, especially in under-served populations, which spreads through collected data. When not properly accounted for, machine learning (ML) models learned from data can reinforce the structural biases already present in society. Here, we present a systematic study of bias in ML models designed to predict depression in four different case studies covering different countries and populations. We find that standard ML approaches show regularly biased behaviors. However, we show that standard mitigation techniques, and our own post-hoc method, can be effective in reducing the level of unfair bias. We provide practical recommendations to develop ML models for depression risk prediction with increased fairness and trust in the real world. No single best ML model for depression prediction provides equality of outcomes. This emphasizes the importance of analyzing fairness during model selection and transparent reporting about the impact of debiasing interventions.

Word order, an essential property of natural languages, is injected in Transformer-based neural language models using position encoding. However, recent experiments have shown that explicit position encoding is not always useful, since some models without such feature managed to achieve state-of-the art performance on some tasks. To understand better this phenomenon, we examine the effect of removing position encodings on the pre-training objective itself (i.e., masked language modelling), to test whether models can reconstruct position information from co-occurrences alone. We do so by controlling the amount of masked tokens in the input sentence, as a proxy to affect the importance of position information for the task. We find that the necessity of position information increases with the amount of masking, and that masked language models without position encodings are not able to reconstruct this information on the task. These findings point towards a direct relationship between the amount of masking and the ability of Transformers to capture order-sensitive aspects of language using position encoding.

Mixture of factor analyzer (MFA) model is an efficient model for the analysis of high dimensional data through which the factor-analyzer technique based on the covariance matrices reducing the number of free parameters. The model also provides an important methodology to determine latent groups in data. There are several pieces of research to extend the model based on the asymmetrical and/or with outlier datasets with some known computational limitations that have been examined in frequentist cases. In this paper, an MFA model with a rich and flexible class of skew normal (unrestricted) generalized hyperbolic (called SUNGH) distributions along with a Bayesian structure with several computational benefits have been introduced. The SUNGH family provides considerable flexibility to model skewness in different directions as well as allowing for heavy tailed data. There are several desirable properties in the structure of the SUNGH family, including, an analytically flexible density which leads to easing up the computation applied for the estimation of parameters. Considering factor analysis models, the SUNGH family also allows for skewness and heavy tails for both the error component and factor scores. In the present study, the advantages of using this family of distributions have been discussed and the suitable efficiency of the introduced MFA model using real data examples and simulation has been demonstrated.

Textual entailment recognition is one of the basic natural language understanding(NLU) tasks. Understanding the meaning of sentences is a prerequisite before applying any natural language processing(NLP) techniques to automatically recognize the textual entailment. A text entails a hypothesis if and only if the true value of the hypothesis follows the text. Classical approaches generally utilize the feature value of each word from word embedding to represent the sentences. In this paper, we propose a novel approach to identifying the textual entailment relationship between text and hypothesis, thereby introducing a new semantic feature focusing on empirical threshold-based semantic text representation. We employ an element-wise Manhattan distance vector-based feature that can identify the semantic entailment relationship between the text-hypothesis pair. We carried out several experiments on a benchmark entailment classification(SICK-RTE) dataset. We train several machine learning(ML) algorithms applying both semantic and lexical features to classify the text-hypothesis pair as entailment, neutral, or contradiction. Our empirical sentence representation technique enriches the semantic information of the texts and hypotheses found to be more efficient than the classical ones. In the end, our approach significantly outperforms known methods in understanding the meaning of the sentences for the textual entailment classification task.